Senior Scientist - NGS for High-Throughput Transcriptomics

Disease Molecular Profiling - NGS & Transcriptomics team

Hays Life Sciences is now looking to recruit a Senior Scientist - NGS for High-Throughput Transcriptomics for a contract assignment until 2023-04-01 with a possibility of extension at AstraZeneca in Gothenburg.

Are you an experienced Molecular Biologist with expertise in Next Generation Sequencing (NGS)? Do you wish to apply this knowledge in a role that is connected to our wider mission to show what science can do? If yes, we might have the role for you!

We seek a talented and highly engaged Molecular Biology/NGS scientist to join the Disease Molecular Profiling - NGS & Transcriptomics team at AstraZeneca in Gothenburg, Sweden. You will contribute with applying molecular biology and NGS expertise to our drug discovery portfolio and working on cutting edge technologies within the field.

What you will do:

* Work collaboratively with scientists from our team, different therapy areas, and computational biology to apply genomic technologies to further drug discovery.
* Develop, evaluate, or implement customized NGS workflows for specific drug discovery projects.
* Plan, design, run, enhance and troubleshoot existing NGS workflows such as bulk RNA-seq (e.g. mRNA-seq, totRNA-seq, ultra-low-input) and high-throughput transcriptomics (e.g. 384-well-based methods).
* Understand and interpret data analyzed by computational biology colleagues and communicate it effectively to project partners and stakeholders.
* Keep records of all lab and technology development work and write technical reports and SOPs.
* Effectively manage timelines and deliver projects according to deadlines.

Essential for the role:

* Ph.D. degree or MSc with experience in Molecular Biology, Biotechnology, Biomedicine or in a relevant scientific discipline.
* Hands-on lab-based experience in utilizing advanced molecular biology RNA-sequencing, DNA-sequencing or Epigenetic sequencing techniques.
* This experience will cover all relevant aspects from hypothesis generation, through experimental design and execution, RNA and DNA extraction, sample and library preparation, sequencing (ideally with Illumina or Nanopore), data handling, post-sequencing QC and troubleshooting.
* Scientifically-driven scientist with attention to details and excellent critical thinking skills.

Desirable for the role:

* Background in applying a broad range of wet-lab techniques, such as mammalian cell-culture, high-throughput in-vitro drug testing, qPCR or automated liquid handling.
* Working with laboratory automation / liquid handling systems, method and technology development and optimization.
* Hands-on experience with Single Cell Transcriptomics or Spatial Transcriptomics.
* Tissue dissection, single cell dissociation, microscopy, flow cytometry/FACS
* Hands-on laboratory experience running NGS platforms (Illumina, Oxford Nanopore etc.).
* Sample Tracking by LIMS systems.