Senior Scientist NMR spectroscopy

Senior Scientist NMR spectroscopy - consultancy role for 12 months for AstraZeneca

Are you a scientist with expertise in, and passion for, the application of NMR to understand and determine the dynamics and structure of therapeutically relevant target proteins? Would you like to apply your expertise to impact and expand the use of NMR in drug discovery projects whilst being presented with a professional development opportunity within a company that follows science and turns ideas into life changing medicines? Then AstraZeneca has a challenge for you!

AstraZeneca is committed to the development of the next generation of innovative medicines and is focused on expanding the use of small molecules to treat dyslipidaemia and familial hypercholesterolaemia. The company currently exploits new avenues for lowering LDL cholesterol in patients at risk of cardiovascular disease in order to provide additional disease treatment opportunities. To help us with this, we are looking for a scientist with passion, expertise and experience to join our Mechanistic and Structural Biology Department (MSB) as a lab-based Senior Scientist on a one-year contract basis within the Biophysics group in Gothenburg, which is part of the global Discovery Sciences area in AstraZeneca's BioPharmaceuticals organisation.

The MSB department has leading capabilities in biophysics, crystallography, cryo-EM, enzymology and cellular pharmacology. The Biophysics team has specific expertise in molecular biophysics methods, including SPR, NMR, ITC, DSF, HDX-MS, nMS and single molecule approaches. We apply biophysics across a range of different modalities to support drug discovery from target validation to drug candidate.

What you will do:

The role as Senior Research Scientist is a laboratory-based position supporting the structure determination of protein-drug complexes in solution utilising NMR spectroscopy. For this we are seeking a highly skilled and motivated NMR spectroscopist to join our Biophysics team on a one-year contract basis. The ideal candidate will have a strong theoretical and practical background in pulse sequences for solution-state NMR, along with extensive experience in the assignment and determination of protein structures using NMR techniques. This role is crucial for advancing our research and development projects in dyslipidaemia and familial hypercholesterolaemia.

You will have a high level of control and influence over the project, allowing you to shape its direction and outcomes significantly. Additionally, you will have ample opportunities to learn new technical skills and develop leadership abilities. Our collaborative and innovative work environment enables you to work alongside scientists and postdocs from various disciplines, both within and across the global AstraZeneca community. This role offers a unique opportunity for professional development in an industrial setting, providing you with a valuable experience and additional skills and helping you build a strong foundation for your future endeavours.

You will be responsible for designing and implementing advanced pulse sequences for solution-state NMR, tailored to our specific research needs. You will perform intricate NMR experiments aimed at the assignment and structural determination of proteins, ensuring precise and accurate data collection. Your expertise will be crucial in analysing NMR data, interpreting results, and integrating these findings with other research data to provide comprehensive insights into the drug mechanism of action. You will collaborate with multidisciplinary teams, contributing to the synthesis of NMR findings with the broader research objectives of this project. Additionally, you will stay abreast of the latest advancements in NMR spectroscopy and protein structure determination, continuously applying this knowledge to enhance our research capabilities.

Your findings will not only support the ongoing project but will also constitute an important part of our publication strategy, aiming for high-impact journal publications. You will document and present your results in both internal and external meetings, playing a vital role in driving our scientific endeavours forward.

Finally, to be successful in this role, we see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal-oriented and problem-solving attitude.

Why AstraZeneca Gothenburg?

With more than 2,400 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthroughs come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

Does this sound like your next challenge? Apply today!