Senior Scientist – Nucleotide Bioanalysis - ligand binding

Presentation

For AstraZeneca we are now looking for a senior scientist in the field of nucleotide bioanalysis and ligand binding. The assignment will start immediately and go on for one year with possibilities for extension.

Interviews and selections are held on an ongoing basis so please apply today!

Arbetsuppgifter

The pre-clinical bioanlaysis and TK group are responsible for the analysis of small molecule drug substances in biological samples generated in support of investigational toxicology studies and Pre Rodent GLP studies. This new role will expand the remit of the team beyond small molecules by including nucleotide bioanalysis for toxicology and PK, PK/PD studies and endcoded proteins for our modified mRNA projects.

You will be responsible for building a new capability for analysis of nucleotide therapeutics and associated endcoded proteins. This will involve:
- defining necessary procedures
- developing analytical methods using ligand binding techniques (e.g. ELISA, DNA hybridisation)
- implementation of the methods and supporting non-clinical studies
- experience of quantitative polymerase chain reaction and mass spectrometry based approaches
- delivering quality in vivo PK data
- support the nucleotide project portfolio
- developing methodology for quantification of oligonucleotide as well as encoded protein in plasma or other matrices
- using state of the art analytical techniques and reports methodology, data and PK evaluation to the customer

You will take a leading role in establishing the science and capability and be involved in developing the strategy for the timing of activities and types of activities. The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the DMPK scientific strategy. The role requires making judgements about complex scientific information sets, developing innovative solutions and applying comprehensive cross-functional understanding. In this role you are responsible for overseeing efficient and timely delivery of appropriate quality data.

Utbildning/erfarenhet

We think that you have a PhD in protein chemistry, molecular biology or similar with expertise in range to technical skills, specifically immunoassay/ELISA platforms (MSD, Gyros, Luminex etc), quantitative polymerase chain reaction, as well as mass spectrometry for analysis of large molecules (nucleotides, proteins, peptides) and other automated processing and analysis equipment. You are used to develope and set up bioanalytical methods for quantitative analysis of nucleotides (oligonucleotides, microRNA, modified mRNA) and endcoded proteins for the modified mRNA projects, provide scientific leadership to scientists, coaching and mentoring for junior colleagues and you have motivational skills. You are additionally experienced in performing problem solving studies by identification of issues and where necessary designing experiments to overcome problems.

You have significant experience in pharmacokinetics and reasonable understanding of PK/PD principle and is used to perform PK and TK calculations including interpretation of the data generated, in collaboration with colleagues in innovative medicines. Excellent communication skills, both verbal and written is necessary.

Förmåner

We take good care of our consultants and we offer social activities, as well as help in planning your future career. Your consultant manager is well experienced from your field, and knows how to get the most out of your assignment.

As a Poolia employee, you are included in the requirements concerning agreements on terms of employment by Unionen. Moreover, you get a grant for working out at your choice of place. You are also covered by a health insurance.

Företagsbeskrivning

Poolia Science can offer several opportunities for skilled people with a background in biochemistry, chemical engineering or science. We work with Sweden’s leading pharmaceutical and life science companies. So whether you’re interested in research, regulatory affairs, quality assurance, environmental and quality control, sales and marketing, or just want a career change, we have the job for you.

Working as a consultant suits whoever wants to get a lot of experience in a short period of time. We offer you the chance to work with well-known brands at renowned companies where you can develop your skills. If you’re looking for a world of exciting assignments and new contacts, you’ll like being a consultant.

Sluttext

Please apply by registering your CV here on our website. Click on the "Ansök" button to the right of this advertisement. It is our recommendation that you register as much information as possible and that you attach a complete CV-document. Please check that your correct e-mail adress is registered.

Poolia is a registered staffing agency, meaning that we comply with the requirements set by Bemanningsföretagen - the Swedish Association of Staffing Agencies.

Language

en-GB