Senior Scientist - Oligonucleotide analytics and purification

Are you a scientist with expertise in, and passion for, Oligonucleotides? Would you like to apply your expertise to impact and expand the use of therapeutic oligonucleotides in drug projects in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca have a challenge for you!

AstraZeneca R&D have been curious about oligonucleotides as a new modality since 2012 and our scientific interest has grown. Therefore, we are now poised to leverage on the wealth of expertise from across our R&D units and through a new matrix organisation to deliver a proprietary Oligonucleotide Therapeutics Platform in-house. We offer a highly rewarding scientific environment along with an inclusive, dynamic and team focused atmosphere - with a goal to design and develop the oligonucleotide therapeutics of the future.

Pharmaceutical Sciences is a function within the AstraZeneca Biopharmaceuticals R&D unit that creates innovative, efficient solutions by transforming molecules into investigative medicines meeting unmet needs of future patients. The function has four departments: Early Chemical Development, Advanced Drug Delivery, Early Product Development and Manufacturing, and Data Science and Modelling. Our wide-ranging portfolio of projects includes traditional small molecules, nucleotide-based therapies and nano medicines across AstraZeneca's therapy areas.

Early Chemical Development (ECD) is a world class CMC department with responsibility for early phase Drug Substance. The department's responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical material, and its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Design, Process Engineering, Route Design and Separation Science. The Separation Science Laboratory supports the design and evaluation of new candidate drugs through purification and characterization of small molecules and New Modalities ranging from microgram to kilogram scale.

As part of the Oligonucleotide capability build expansion, we are now looking for an Senior Scientist to join our fantastic team in Gothenburg, Sweden.

Who are you?

We are looking for a candidate with a background in Analytical Chemistry with demonstrated expertise applied to the purification and characterization of synthetic Oligonucleotides. We are looking for a candidate who is a specialist in this area. This is a lab-based role where you will facilitate the delivery of Oligonucleotides with right quality to our portfolio projects.

Essential for the role:

* PhD in Analytical Chemistry or equivalent experience from industry
* Significant practical experience in Oligonucleotide or biomolecule analytical measurement and purification science
* Knowledge of the synthesis and manufacturing environment for Oligonucleotides
* Strong collaborative and communication skills with ability to operate across functional boundaries
* Strong influencing and prioritisation skills to ensure timely delivery
* Excellent English, both spoken and written

Desirable for the role:

* Experience from working with preparative chromatography, both low and high pressure
* Knowledge in different analytical techniques; e.g. IP-LC, HILIC, IEX, SEC, LC/MS and high-resolution mass spectrometry
* Hands-on experience from solid phase synthesis of Oligonucleotides
* Interest in automation and data processing

What's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.
If you are interested, apply now!
Please note applications must include your CV and a cover letter which presents you and your key areas of strength / development and why you should be considered for the role!
For more information about the position please contact hiring manager Hanna Leek, Hanna.Leek@astrazeneca.com. Welcome with your application no later than March 2nd 2021.

Find out more about us here

Our Gothenburg site: https: //www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https: //www.movetogothenburg.com/
A life changing day: https://www.youtube.com/watch?v=QulX8EotRSE
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.