Senior Scientist - Sample preparation & protein homeostasis

At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider mission to show what science can do. Do you want to join our journey?

We are recruiting for a motivated Senior Scientist to join us in the Mechanistic and Structural Biology department within the Discovery Sciences organization in Gothenburg, Sweden. Our focus is to provide quality data to drive chemistry optimization in drug discovery projects. Leading from the bench, our new colleague will combine good communication and team-working skills with a passion for scientific excellence, delivery and innovation.

With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines - for the world's most complex diseases.

What you will do:
This is a senior lab-based role with focus to support our drug discovery projects with quantitative measurements of intracellular protein levels and their turnover to understand response to treatment. Of relevance to this role is the determination of absolute levels of a chosen (targeted) set of proteins of interest using suitable technology.

The successful candidate has demonstrated skills in sample workup from both in vitro and in vivo samples. You´ll also be expected to take initiatives towards improvement of novel sample preparation routines and to work strategically towards improving capacity and throughput of measurements.

Essential in the role:

* Ph.D. and extensive experience in the area of cell biology, in vitro pharmacology and protein homeostasis.
* Expertise in the design, development and validation of cellular assays for compound profiling.
* Extensive experience in protein sample preparation from cell lysates and tissues and a thorough understanding of available approaches for enrichment.
* Broad scientific knowhow of available technologies for quantitative assessment of protein levels and hands-on experience from multiple approaches.
* Biological mass spectrometry expertise, with prior application of absolute quantification.

Besides a solid scientific track record, we also believe that you bring an external network of relevance to this position and have a demonstrated ability to build trusting relationships with scientific colleagues. You should have ability to work effectively in a multi-disciplinary research environment. Scientific visibility and leadership through project contributions and external publications is a great plus.

Desirable in the role:

* Prior experience of working with high-resolution protein mass spectrometry.
* Expertise in protein turnover measurements using the SILAC approach.
* Track record of identifying and adopting scientific and technical advances.

Why AstraZeneca?
With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. There's no better time to join our global, growing enterprise as we lead the way for healthcare and society.

So, what's next? Does this sound like your next challenge - welcome to apply today!

We look forward to your application, but no later than 12th June, 2022.

For more information about the position please contact Thomas Lundbäck at thomas.lundback@astrazeneca.com

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html