Senior Scientist - Stem Cell Biology and Genome Engineering

Are you an experienced scientist in the field of stem cells and gene editing? Would you like to combine your scientific skills & drive the development genome-engineered pluripotent stem cells for in vitro disease-modelling? This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences team in Translational Genomics as a bench-based Senior Research Scientist. In this role you will be a key player in developing stem cell models for target discovery and validation.

We are part of the broader Discovery Sciences organisation and you will be working alongside our stem cell scientists, disease area specialists and genome editing group. By sharing and increasing our knowledge we are empowered to be the best we can be and accelerate progress. Welcome to join our exciting journey!

What you will do:
Using your strong knowledge and experience in stem cell biology, cell model development and CRISPR technology you will have the opportunity to work on stem cell model development for target validation projects. This includes culture and differentiation of induced pluripotent stem cells (iPSCs), genome engineering of iPSC lines, and differentiation of target cell types at scale.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects and your performance in in vitro studies to investigate the effects of CRISPR-based gene editing on gene and protein expression, and cellular readouts.

Additional Responsibilities:

* Culture and differentiate human iPSC lines to target cell types including cardiomyocytes and skeletal muscle. Experience with large-scale differentiation platforms preferred.
* Culture human primary cells and various mammalian cell lines.
* Genome engineering of iPSC lines and clonal cell line generation
* Perform molecular biology protocols in support of in-house quantitative PCR, digital PCR and NGS assays.

Essential in the role:

* MSc/PhD degree with significant experience in Developmental Biology, Cell Biology, or Gene Editing.
* Experience with the culture of multiple mammalian cell types including primary cells.
* Hands-on experience with the following assay platforms: RT-qPCR, ELISA, Western blots, Flow cytometry and/or cell- based functional/ potency assays.

We also see that our new colleague have ability to effectively communicate, be collaborative and a strong team player. You should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organizational, data and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Desirable in the role:

* Expertise with liquid handling automation technologies.
* Experience of setting up cell based pharmacological assays.

Why AstraZeneca?
Here we get to develop and grow - whether that's working at the leading-edge or on varied stages and molecules. Working on things that have never been done before. Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

So what's next? If this sounds like the next job and place for you, welcome to apply today!

We look forward to get to know you better - please send your application to us no later than 13th November, 2022.

For more information about the position please contact hiring manager Bilada Bilican.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html