Senior Scientist - Stem Cell Biology & Neuroscience

Are you a skilled and motivated scientist experienced in the field of pluripotent stem cells (PSC)? Would you like to use your scientific skills to drive the development of stem-cell derived neural models for therapeutic development and join a fantastic team of scientists? If yes, this might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity to join us in the Applied Stem Cell Sciences team in Discovery Sciences, Biopharmaceuticals R&D. As a bench-based Senior Research Scientist you will be a key player in developing stem cell models for neuroscience applications.

Our team belongs to the wider Discovery Biology department with a common goal to innovate at the interface of science and technology. Our mission is to discover new targets, to create reagents, assays and disease models to discover new medicines, and to develop cell and gene therapies. Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

What you will do:
The role is focused on laboratory-based activities and your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

As a Senior Research Scientist you'll be working alongside our stem cell scientists, disease area specialists and genome editing group. Using your great knowledge and experience in stem cell biology, cell model development, and primary cell culture you will have the opportunity to work on in vitro assay development for neuroscience applications. This includes culture and differentiation of induced pluripotent stem cells (iPSCs), primary neuronal cultures and carrying out gene editing experiments where necessary.

Essential in the role:

* MSc/PhD degree with significant experience in Neuroscience, Developmental Biology or Cell Biology.
* Proven experience with human PSC biology and differentiation to neural cell types.
* Experience with primary neuronal cultures.
* Experience in developing biochemical and cell-based assays in primary and PSC-derived neurons, introducing agents by viral transduction or transfection;

* Proficiency in cellular and molecular biology techniques, including qPCR, ELISA, Western blotting, Flow cytometry, routine immunofluorescence and IHC staining


* Perform in vitro studies to investigate the effects of CRISPR-based gene editing on gene and protein expression and cellular readouts.
* Effectively collaborate within a matrixed research team to facilitate the success of projects. Maintain complete experimental records.

We also see our new peer as collaborative and communicative, sharing our view of the importance in being a strong team player. Alongside you scientific passion, the ability to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude is of great use.

The following skills are highly desirable:

* Experience with CRISPR gene editing, clonal cell line generation, and NGS library prep.
* Expertise with liquid handling automation technologies.
* Experience of setting up cell based pharmacological assays.

Why AstraZeneca?
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So what's next? If this sounds like the next job and place for you, apply today!

We look forward to get to know you better - please send your application to us as soon as possible, but no later than 22nd May, 2022.

For more information about the position please contact Anna Forslöw at anna.forslow(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html