Senior Synthetic Chemist - Medicinal Chemistry

Do you have a strong synthetic chemistry expertise? Would you like to use your expertise to develop drug conjugates containing small molecules, peptides, proteins or oligonucleotides in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer a unique opportunity for a senior scientist with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry in design of drug modalities and conjugates. As part of an open minded, creative and experienced team in New Modalities drug discovery, you will contribute with your high ambitions, collaborative attitude and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden in the therapy area of Cardiovascular, Renal and Metabolism (CVRM).

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides, and drug conjugates. In recent years we have expanded our investments in targeted drug delivery requiring expertise in synthesis and design of various molecular conjugates.

We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the forefront of science.

What you'll do

The role is lab based and focused on synthetic chemistry of various modalities and drug conjugates. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment. In addition, you are expected to be part of external collaborations, publish scientific papers, present, and represent the department externally.

Essential for the role

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry applied across multiple modalities and handling of complex molecules.

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Ph. D. degree in Organic Chemistry, Medicinal Chemistry, Chemical Biology with emphasis on synthesis.
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Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
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Scientific creativity: ability to identify, develop and apply new technologies and ways of working
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Great awareness of recent literature as well as current developments and trends in organic synthesis
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Highly self-motivated and capable of analyzing complex data and deciding on focused course of action
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Excellent teamwork, collaboration, networking and communication skills

Desirable for the role

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Experience with oligonucleotide chemistry
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Experience from developing new chemistry for conjugations of different modalities e.g. peptides, oligonucleotides, small molecules, proteins or antibodies

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information, please contact Associate Director, Ranganath Gopalakrishnan through +46-31-7761000

Welcome with your application no later than Jun 11th, 2023

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.