Senior Synthetic Chemist-Medicinal Chemistry of drug conjugates

Would you like to apply your strong synthetic chemistry expertise in conjugation chemistry in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We now offer a exciting opportunity for a senior scientist with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry in design of drug conjugates. As part of an open minded, creative and experienced team in New Modalities drug discovery, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden in the therapy area of Cardiovascular, Renal and Metabolism (CVRM).

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides and drug conjugates. In recent years we have expanded our investments in targeted drug delivery requiring expertise in synthesis and design of various molecular conjugates.

We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

What you'll do

The role is lab based and focused on synthetic chemistry of various modalities and drug conjugates. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment. In addition, you are expected to be part of external collaborations, publish scientific papers, present and represent the department externally.

Essential for the role

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry applied to conjugation chemistry and handling of complex molecules.

* Ph. D. degree in Organic Chemistry, Medicinal Chemistry or Chemical Biology with emphasis on synthesis.
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Experience from developing new chemistry for conjugations of peptides, oligonucleotides, small molecules, proteins or antibodies is a plus.
* Great awareness of recent literature as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of analyzing complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact Team Leader Ranganath Gopalakrishnan or Associate Director Laurent Knerr through +46-31-7761000

Welcome with your application no later than July 25th, 2021

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Meet Hasse, Chemist at AstraZeneca Gothenburg: https://www.youtube.com/watch?v=QulX8EotRSE&list=PLgfkdJlwmkT6h7sZKBXqs7Xj4PobD4RmR



Why AstraZeneca?

AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.