Senior Synthetic Chemists in Medicinal Chemistry

Would you like to apply your synthetic chemistry expertise in a global company where we work together across boundaries to make the impossible a reality? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

AstraZeneca now offer several exciting opportunities for senior scientists with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry into design and synthesis of new candidate drugs. We are further expanding our teams to support both classical small molecules projects and New Modalities chemistry working on drug conjugates and targeted drug delivery. As part of an open minded, creative and experienced team, you will contribute with your high ambitions, collaborative mindset and enthusiasm to push the boundaries of science in the area of synthetic and medicinal chemistry. The positions are placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca´s core therapy areas. We follow the science and turn ideas into life changing medicines for patients suffering from Heart Failure, Diabetes and Chronic Kidney Disease. We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules to identify and validate novel biological targets. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality which opens opportunities for creative synthetic chemists.

What you'll do

The role is lab based and focused in the area of medicinal chemistry with emphasis on synthetic chemistry. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, Discovery Sciences, DMPK and Pharmaceutical Sciences departments.

There will also be opportunities to develop medicinal chemistry and drug discovery knowledge together with the experts in the department. In addition, you are expected to be part of external collaborations, publish scientific papers, present and represent the department externally.

Depending on your previous experience you will be focusing on small molecules or New Modality chemistry, specifically drug conjugates and targeted drug delivery.

Essential for the role

We are looking for an ambitious team player that have expert knowledge in synthetic organic chemistry. Basic knowledge in medicinal from drug discovery in an industrial setting.

* Ph. D. degree in Organic Chemistry or Medicinal Chemistry with focus on the synthetic chemistry component. Relevant post-doctoral experience in academic or industrial setting is preferred.
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Experience from New Modalities chemistry such as conjugations of peptides, RNA or small molecules is seen as an advantage for one of the positions, but not a prerequisite.
* Great awareness of recent literature within synthesis/medicinal chemistry as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of receiving and analyzing input from complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information about the position please contact Associate Director Laurent Knerr or Principal Scientist Magnus Johansson through +46-31-7761000

Welcome with your application no later than February 25, 2021

Where can I find out more?

Our Gothenburg site: Link

Life in Gothenburg: Link

Culture and atmosphere of the Gothenburg site: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail.