Solid State Experts PD Inhalation Unit

The Arena

AstraZeneca is currently making large investments to increase our research capability in Inhaled Pharmaceuticals, in Mölndal, Sweden. We are investing in new equipment, new technologies and more people. We now aim to increase the number of people working with Product Development for Inhalation by 50%. We therefore seek people with knowledge in various skills relevant for inhaled drug delivery, such as formulation science, analytical chemistry, solid state properties, device development and biopharmaceutical sciences.
AstraZeneca Mölndal is one of AstraZeneca?s three core sites for drug research, with about 2.500 employees at site. At Product Development, Sweden, a sub-division of Pharmaceutical Development, we focus on the fields of Cardiovascular and Metabolic Diseases and on Respiratory, Inflammatory and Autoimmune Diseases. Within Product Development Inhalation we have an exciting pipeline, consisting of both new molecules and new devices. The unit currently comprises 80 people, dedicated to research and development for new inhaled drug products and we want you to be a part of growing our expertise in this area.

The Role

Product Development is looking for an enthusiastic Solid State/Material Science Expert who, along with having significant project responsibility, will provide input in the area of solid state/material science during the formulation development of orally inhaled drug products.
The role is primarily laboratory based, where a combination of theoretical and technical expertise in material science is a must, as e.g. the solid-state composition of a powder inhalation formulation is considered to be one of the critical quality attributes.
More specifically, you will:

Be able to apply toolbox techniques such as thermal methods, vapor-gas sorption, diffraction and spectroscopy, coupled with in silico software simulation, to provide high quality input to formulation development

Have an expert understanding of solid state matter and associated phase transitions, including e.g. molecular to macroscopic material properties of condensed matter in unary and multi-component systems.

Provide expertise in characterization of the amorphous phase resulting from secondary processes or specialized unit operation used for inhalation, either via mechanical stress with partial disorder or materials presenting glassy state behaviors (e.g. resulting from spray drying) and link to associated macroscopic properties relevant for inhaled particles.

Have the ability to apprehend powder behavior especially for optimum aerosolization properties and deposition characteristics, optimized during design of particle interactions driven by particle size (including nanomaterials), density, morphology, composition, surface properties.

The successful applicant will be given the opportunity to contribute to the long-term strategy plans via solid state/material science networks, representing specific inhalation demands in this field, linking science to drug project needs.

For full job description and to apply, please visit www.astrazeneca.se