Sr Research Scientist NGS/Transcriptomics - Oligonucleotides

Are you an engaged scientist with Next Generation Sequencing experience? Do you want to explore and develop the science of selected oligonucleotides and have a passion to drive scientific questions? Welcome to join us at AstraZeneca!

We seek a highly motivated Senior Research Scientist to join the NGS & Transcriptomics team within the Translational Genomics Department in our Discovery Sciences R&D organization in Gothenburg, Sweden. You will apply proven molecular biology and NGS expertise to the characterization and profiling of the effects of oligonucleotide treatment in in vitro biochemical and cellular assays.

The NGS & Transcriptomics team's remit is the development and application of nucleic acid "omics" technologies and processes to generate smart data that will enrich our understanding of drug pharmacology, target mechanisms, model systems, patients and disease. We offer a highly exciting scientific environment with ample learning opportunities and an expectation to publish new findings.

What you will do:
This role is a scientific specialist in the NGS/Transcriptomics area - a hands-on lab-based role at the forefront of NGS /Transcriptomics technology with a focus on effective delivery, troubleshooting and putting ideas into action. In this role, you will implement NGS methods tools and strategies applied to projects sought at identifying novel oligonucleotide based therapies.

With your significant expertise within the NGS/Transcriptomics field you will actively be involved in the planning and execution of NGS projects. And apply cutting edge technologies and methodologies to establish a high efficiency qPCR oligonucleotide screening capability in the NGS & Transcriptomics team. As well as design and execute NGS experiments to explore the science of selected oligonucleotide; including - primary and secondary mechanistic impacts and off target effects.

We also rely you to:

* Apply this HT-qPCR capability to the activity screening of oligonucleotide libraries to discover novel hits.
* In applying this NGS analysis leverage the full capabilities of the NGS & Transcriptomics team as required (including bulk RNA-seq, single cell technologies, epigenetics, and advanced transcript variant detection).
* Build strong collaborative relationships with the project investigators, key partners, project bioinformaticians and data scientists to ensure the smooth running of projects.
* Perform cell-based work to maintain, propagate and treat commercial and primary cell lines.

Essential in the role:

* Candidates should have a Ph.D. degree or corresponding experience in a relevant scientific field.
* At least 3 years hands on expertise with a broad range of Next Generation Sequencing /Transcriptomics technologies (e.g.HT-qPCR, RNA-Seq, DNA-Seq, epigenetic, single cell and long read technologies).
* This experience will cover all relevant aspects from hypothesis generation, through experimental design and execution, sample and library preparation, sequencing, data handling, post sequencing QC and trouble shooting.
* Hands on experience with cell culture work.
* Strong evidence of experimental impact through a track record of High-Quality publications, internal and external presentations.
* Significant experience of NGS technology development and innovation.

The successful candidate also have great communication skills and an ability to operate effectively in a multi-disciplinary research environment. You are a person who demonstrate a passion for driving scientific questions, combined with strong team working ethics, to drug discovery projects.

Does this sound like the job and place for you? Apply today!

We look forward to your application, but no later than 17th January, 2021.

For more information about the position please contact Graham Belfield at +46 708 808733 / Graham.Belfield@astrazeneca.com, or Alessandro Bonetti at +46 722 009864 / Alessandro.Bonetti@astrazeneca.com

Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to develop a working environment that furthers collaboration, openness and innovation. Therefore, we have built space for meetings, and socializing, where spontaneous meetings can give birth to new innovations.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/

NOTE - Due to the holidays coming up, the screening process will take a bit longer than usual. Please bear with us and we will get back to you as soon as possible when we are back in January.