Sr Synthetic Chemist in discovery of oligonucleotide conjugates

Senior Synthetic Chemist in Medicinal Chemistry of oligonucleotide drug conjugates

Are you an experienced Synthetic Organic Chemist with deep knowledge of Medicinal Chemistry? Can you envision applying your skills into drug discovery, to develop novel drug conjugates between various modalities such as small molecules or peptides linked to oligonucleotides. Then this is an outstanding opportunity for you!

At AstraZeneca, we follow the science to explore and innovate. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

Our Early Cardiovascular, Renal and Metabolism (CVRM) Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. Here, we work agnostic to molecular modality and have expertise in small molecules, PROTACs, peptides, oligonucleotides and drug conjugates. We drive our pipeline and areas of scientific leadership internally and in partnership with world experts which provides you as a scientist with the unique opportunity to stay at the fore-front of science.

You will be based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.

What you'll do

The role is lab based and focused on synthetic chemistry of various modalities across projects, including conjugates of therapeutical oligonucleotides. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation.

All work is done in a highly cross disciplinary environment. In addition, you will be part of external collaborations, publish scientific papers, present and represent the department externally.

As part of an open minded, creative and experienced team in drug discovery, you will contribute with your high ambitions, collaborative mentality and passion to push the boundaries of science in the area of synthetic and medicinal chemistry.

Essential for the role

We are looking for ambitious colleagues who have expert knowledge in synthetic organic chemistry applied across multiple modalities and handling of complex molecules.

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Ph. D. degree in Organic Chemistry, Medicinal Chemistry or Chemical Biology with emphasis on synthesis.
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Strong synthetic chemistry knowledge: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
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Scientific curiosity and creativity: ability to identify, develop and apply new technologies and ways of working
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Experience from developing new chemistry for conjugations of different modalities e.g. peptides, oligonucleotides, small molecules is an advantage
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Great awareness of recent literature as well as current developments and trends in organic synthesis
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Highly self-motivated and capable of analyzing complex data and deciding on focused course of action
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Excellent teamwork, collaboration, networking and communication skills
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Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents

Desirable for the role

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Experience of oligonucleotide chemistry

Why AstraZeneca

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe - with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations.

We offer competitive salaries and excellent benefits, such as extra paid Holiday, Private Medical Benefit, on site exercise and much, much more.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

For more information please contact Associate Director Ranganath Gopalakrishnan or Director Laurent Knerr through +46-31-7761000

Welcome with your application no later than January 3rd, 2022

We will review applications continuously, however and the application period is extended due to the upcoming Holiday season, which may delay our communication.

Where can I find out more?

Our Gothenburg site: Link

Relocate to Gothenburg: Link

Make a move to Global Gothenburg: Link

Life in Gothenburg: Link

Meet Hasse, Chemist at AstraZeneca Gothenburg: Link