Synthetic Chemist - Expert on DNA encoded library synthesis

Do you have hands-on experience and great knowledge with synthesis of DNA encoded libraries? Are you interested to establish and develop our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? Welcome to AstraZeneca!

We are seeking a specialized Synthetic Chemist that will play an important part in our iLAB (Innovation Lab) team, focusing on the synthesis of novel DNA encoded libraries (DEL). You have the opportunity to drive and establish the DEL synthesis capabilities in a new lab at AstraZeneca in Gothenburg and contribute to the production of a proprietary compound collection based on DEL.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities and varied work. You will be valued. Not only for your unique contribution, skills and background, but because we recognize people are our greatest asset. Here we are dedicated to being a Great Place to Work.

What you will do:
This is an exciting role where you will drive the set up and development of the new DEL synthesis lab capabilities at AstraZeneca Gothenburg. You will design and synthesize DNA encoded libraries - and use and develop currently available chemistry automation for DEL synthesis. You will also contribute to the continuous improvement of the DEL synthesis platform by developing and applying new , cutting edge synthetic approaches for on-DNA chemistry and by evaluating new technologies.

In your daily work you will troubleshoot laboratory-based problems and make a significant contribution to the delivery of the team. As DEL Chemist, you will maintain access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Essential on the role:
You're a chemist with a track record of applying innovative chemistry solutions, with resulting impact in project delivery. You also have:

* Ph.D. in a relevant chemistry discipline, or a Master degree in chemistry with minimum 5 years' experience in synthetic organic chemistry
* Hands-on experience with on-DNA synthesis and/or synthesis of DNA encoded libraries.
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical sciences.
* Expertise in parallel chemistry
* Knowledge of basic molecular biology techniques e.g gel electrophoresis, DNA ligation, PCR.
* Advanced knowledge of modern chemical literature, chemical technologies and applying new ideas to project delivery.
* A track record of driving innovation in chemistry related sciences.


The successful candidate should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific fields to get results. We also believe that our candidate have effective levels of communication, a scientific drive and a high interest in working with organic chemistry and molecular biology techniques.

Desirable in the role:

* Experience in the development of on-DNA chemistry.
* Experience in methods development.
* Experience with chemistry automation.
* Knowledge in designing high-throughput chemistry and/or library synthesis experiments using bespoke design software.
* Knowledge of medicinal chemistry

We also believe that the successful candidate have a detailed understanding of the chemical sciences and how they contribute and influence drug discovery together with knowledge of the drug discovery process.

Why AstraZeneca Gothenburg?
Our spectacular campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from over 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. The site itself is designed with collaboration in mind: from the Coffee Lab to the gym, we have built a series of environments where innovation can happen.

Does this sound like your next challenge? Apply today!

Welcome with your application, but send it to us no later than 4th April, 2021.

For more information about the position please contact Nidhal Selmi, Compound Collection Enhancement programme manager - iLAB, at nidhal.selmi@astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html
About iLAB - Innovation Lab: https://www.astrazeneca.com/r-d/our-technologies/ilab.html