Synthetic Medicinal Chemist at EpiEndo Pharmaceuticals

EpiEndo Pharmaceuticals is a clinical stage pharmaceutical company with a unique focus on impairment of epithelial barriers as a common mechanism of many inflammatory conditions such as the airway, gastrointestinal tract tract and skin. Our lead drug EP395 is currently in Phase 1 and we wish to expand our platform in discovery of potential new candidate drugs. Thus, we are looking for a Synthetic Medicinal Chemist to join us on this exciting journey.

EpiEndo is an Icelandic company headquartered in Reykjavík, but with several team members working remotely across Europe. However, we meet regularly face to face and we have a great team working closely together despite long distance!

About The Opportunity

We are looking for synthetic medicinal chemist to join our early research team. Highly motivated, passionate organic chemist holding PhD in Natural products & heterocyclic chemistry with hands-on experience in multi-step synthesis, from milligram to multi-gram scale. Additional experience in route-scouting or medium-scale synthesis would be a plus, as well as other specific skills such as parallel synthesis, solid phase synthesis and conjugation chemistry. Previous experience in industry is required. The successful candidates must demonstrate their capabilities in problem-solving and in working in an autonomous manner. The position is a full time employment and you will report to our head of Chemistry. The role is located in Stockholm/Solna.

Job description

As one of the Synthetic Medicinal Chemist you will:

Synthesis, purification and analysis of novel chemical entities

Working closely with designated cross-functional project teams to deliver synthetic chemistry part of projects in timely fashion in accordance to highest industry standards

Independently manage your workload, design and perform bench activities independently, able to drive novel research strategies

Share responsibilities for the chemistry lab, equipment maintenance and chemical inventory management in a team environment within a shared facility

Have excellent oral and written communication skills, including writing, reviewing and editing scientific documents in English

Be able to effectively communicate results and drive thoughtful discussion during project team meetings

Be familiar with chemistry related softwares, and reference management tools

Keep detailed data collection, organization, and experiment documentation (MS Office, electronic laboratory notebook)

Be able to work on projects in close collaboration with internal as well as external partners like Contract Research Organization, and Academic Research Organizations

Enjoy laboratory work

Desired and Required Qualifications

Education

? M. Sc in Organic chemistry

? PhD in Natural products & heterocyclic chemistry

? Preferably specific training and education in biophysical assays

Experience

? Minimum 5 years of international postdoctoral experience

? Previous experience in working in small pharmaceutical R&D is crucial

? Earlier experience in both Solution phase synthesis and Solid phase synthesis essential

? Experience on targeted delivery and drug conjugates (with small molecules, peptides and proteins) required

? Experience in click chemistry, synthesis of macrocycles, peptidomimetics, natural products, heterocycles, and fluorescent probes is vital

? Familiar with SAR, bioisosteric replacement, and Hit to Lead optimization

? Proven track record of synthetic medicinal chemistry from a highly collaborative environment

Preferred Skills and Competencies

? Essential competencies in modern organic synthesis and chromatographic purification
? Ion exchange chromatography, Size Exclusion chromatography, Flash chromatography and Reverse phase semi-preparative HPLC highly desirable

? Competent in using instruments NMR, LC-MS, GC-MS and IR

? Excellent oral and written communication skills in English

? Strong organizational skills

? Ability to deliver on goals and timelines


About EpiEndo

EpiEndo is a clinical-stage biopharmaceutical company with a unique approach to inflammatory disorders that focuses on enhancement of epithelial barrier integrity as a causal pathophysiological factor underlying the etiology of several major diseases. Epithelial cells are a key component of the barrier that makes up human skin and lung tissue, as well as the intestinal tract and genitalia. Compromised integrity of this barrier is implicated in the progression and non-resolution of inflammation.

EpiEndo is developing a proprietary portfolio of orally available drug candidates with promise as first-in-class disease-modifying therapeutics, to address the huge global burden of chronic respiratory diseases and other significant unmet medical needs.

EpiEndo's lead drug candidate, EP395, aims to be the first on-market oral, disease modifying, barrier strengthening and anti-inflammatory drug for chronic obstructive pulmonary disease (COPD).

For more information, please visit www.epiendo.com


Application & Contact

Please send your CV and cover letter to jobs@epiendo.com.

Closing day for applications is 31:st March, 2022.
No agencies or recruiters please.