Thesis work: Feed Screw Modelling in CDC using DEM

Job description
Feed Screw Modelling in Continuous Direct Compression using Discrete Element Method


Thesis type: 30 credits
Project start: January 2024
Student location: On Site, Gothenburg Sweden


Background:
Continuous Direct Compression (CDC) is a manufacturing process used predominantly in the pharmaceutical industry to produce solid dose pharmaceutical products. One of the critical components in CDC is the feed screw. The feed screw, often non-cylindrical with uniquely pitched edges, plays a crucial role in the compaction process. It is typically equipped in a hopper and helps force the feeding of materials into the gap between the rollers. The screws allow building up pressure, densifying the materials, and improving the feed to the rollers. This mechanism aids in driving the powder-stock into the compaction area. Pre-densification and deaeration occur in the screw feed region during operation. The results would enable a better understanding of the segregation of particle, stresses experienced by particles which could potentially lead to particle breakage and mass flow rate through the feeder.


Thesis Objective:
The primary goal of this master’s thesis is to develop a comprehensive process simulation framework for feed screw modelling using the Discrete Element Method (DEM) modelling technique. The selected candidate will be expected to utilize their knowledge in modelling and simulation and data analysis to accomplish the following,
Modelling: Develop accurate material models that capture the feeding behaviour through the feed screws using DEM.
 Process Simulation: Use the developed model to simulate feeding through the feed screw as a function of particle characteristics such as particle size distribution, agglomeration and breakage. 
Validation: The results would be compared and validated through in-house experiments and/or data from literature. 


Business Value:
The study would enable to establish a better understanding of the powder processing through feed screw in CDC which could help in predictions based on the material characterisation. 

At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.


With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.


Application
Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad’s website.


Deadline for application: 2023-10-16, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.



Responsibilities

The primary goal of this master’s thesis is to develop a comprehensive process simulation framework for feed screw modelling using the Discrete Element Method (DEM) modelling technique. The selected candidate will be expected to utilize their knowledge in modelling and simulation and data analysis to accomplish the following,
Modelling: Develop accurate material models that capture the feeding behaviour through the feed screws using DEM.
Process Simulation: Use the developed model to simulate feeding through the feed screw as a function of particle characteristics such as particle size distribution, agglomeration and breakage. 
Validation: The results would be compared and validated through in-house experiments and/or data from literature.




Qualifications


Enrolled in a Mechanical Engineering, Chemical Engineering, Physics or similar program at a master’s Level.
Proficiency in modelling preferably DEM.
Motivated, self-driven, and capable of working both independently and collaboratively


About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 


At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.