Thesis work: Genome-wide NGS approaches for CRISPR detection

Job description
Thesis Work: Genome-wide NGS approaches for CRISPR off-target detection 

Are you passionate for the development of advanced Next Generation Sequencing (NGS) technologies to support gene editing programs strategy? Would you like to apply expertise to innovate sequencing-based techniques in a company that turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!

Thesis type: 60 credits
Project start: January 2024
Student location: On Site, Gothenburg Sweden

Translation of CRISPR-Cas9 technologies into therapies requires sensitive detection of unintended mutations across the genome. Developing state-of-the-art NGS-based methods to discover CRISPR off-targets genome-wide is of high priority for developing safe editing programs at Discovery Sciences.

To help us in this challenge, we are looking for a highly motivated and engaged Master student to join our collaborative Disease Molecular Profiling team - NGS/Transcriptomics Function at AstraZeneca, in Gothenburg. You will be part of a dynamic team working on transformative NGS platforms to enable acceleration and innovation of our R&D pipeline.

To this end, you will be actively involved in the establishment and evaluation of customized NGS workflows, as well as in the enhancement and troubleshooting of existing ones. An important part of your work will include data interpretation in collaboration with our team of computational biologists and effective communication of progress and milestones to stakeholders.

You will be expected to work collaboratively within a multient, sharing insights and contributing to the discussion of the team’s projects. Keeping up to date with relevant scientific literature and technological advancements in the CRISPR field will be part of your tasks.

At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.
 
With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.

Application
Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad’s website.

Deadline for application: 2023-10-16, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.



Responsibilities
We are looking for a highly motivated and engaged Master student to join our collaborative Disease Molecular Profiling team - NGS/Transcriptomics Function at AstraZeneca, in Gothenburg. You will be part of a dynamic team working on transformative NGS platforms to enable acceleration and innovation of our R&D pipeline.

To this end, you will be actively involved in the establishment and evaluation of customized NGS workflows, as well as in the enhancement and troubleshooting of existing ones. An important part of your work will include data interpretation in collaboration with our team of computational biologists and effective communication of progress and milestones to stakeholders.

You will be expected to work collaboratively within a multidisciplinary department, sharing insights and contributing to the discussion of the team’s projects. Keeping up to date with relevant scientific literature and technological advancements in the CRISPR field will be part of your tasks.

Qualifications
Essential Requirements
• Hands on experience in molecular biology or genomics-focused setting
• Familiarity with CRISPR-Cas9 technology and its applications

Desirable Requirements  
• Familiarity with NGS technology and automated liquid handling systems.
• Prior experience in multidisciplinary work environment

About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 

At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.