Thesis work: In vivo CRISPR screening

Job description
In vivo CRISPR screening using a customized barcoded library

The Genome Engineering laboratory at the AstraZeneca, Gothenburg, is looking for a Master student to participate in a project to design and use a customized barcoded CRISPR library for in vivo screens.

Are you passionate about the Nobel-prize winning science of genome-editing and its aplications to study human disease. Would you like to apply your expertise to impact the oncology studies in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!

Responsibilities
Business area
Genome Engineering, Oncology, Functional Genomics, CRISPR

Main Duties and Responsibilities
Genome-sequencing has catalogued somatic genomic alterations in human diseases. However, identification of these mutations does not reveal their functional importance. CRISPR-Cas9 screenings are used to study the function of genes at large scale. During this master thesis, you will be involved in designing and cloning a customized barcoded guide RNA library for CRISPR-Cas screening. Such library will be used for drug resistance screening for oncology applications. During the project you will be exposed to the state of the art molecular biology techniques such as library cloning, cell culture and next generation sequencing.

Qualifications
Essential Requirements
Candidate must be pursuing a master degree in any branch of biological sciences
Highly motivated and strong interest in the application of genome engineering in curing the human diseases
Knowledge of molecular biology techniques, cell culture and basic understanding of CRISPR-Cas


Desirable Requirements
Working knowledge of computer softwares like microsoft office


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only accept applications through Randstad’s website.

Deadline for application: 2020-10-28, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson kerstin.karlsson@randstad.se or Linnea Öster linnea.oster@randstad.se

About the company
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our “walk and talk” meeting trail.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.