Thesis work: The molecular mechanisms of cardiotoxicity

Job description
Investigation of the molecular mechanisms of cardiotoxicity utilizing novel cardiovascular in vitro models and technology platforms  


If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us!


Thesis type: 60 credits
Project start: September 2023
Student location: On Site, Gothenburg Sweden



Damage to the cardiovascular system either structural or functional in nature by drugs (drug-induced cardiotoxicity) is an important concern during drug development. There is an unmet need to identify potential factors and gain molecular understanding of mechanisms underlying drug-induced cardiotoxicity. Within the cardiovascular safety team at AstraZeneca, we see the potential of integrating improved physiologically relevant cell models that more accurately recapitulate the patient population (i.e. disease background), with omics approaches to help more accurately predict drug-induced toxicology early in drug discovery, enabling optimal compounds to progress into clinical development.  


This role will be within a global R&D department, Clinical Pharmacology and Safety Sciences, supporting all AZ therapy areas from early stage to late stage drug discovery to bring safe and efficacious medicines to patients.


At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.


With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.


Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad’s website.


Deadline for application: 2023-04-16, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.



Responsibilities
In this graduate role, you will generate advanced cardiovascular models (healthy or diseased) representative of the key cell types in the heart using both stem cell derived cells and primary cells, and characterize their response to drug-induced injury utilizing a variety of state-of-the-art technology platforms. You will be at the forefront of innovative medicines working with experts across global multi-disciplinary teams in the fields of cardiac biology and toxicology. From this cutting-edge work there is the potential for publication in high-impact journals and influence the future direction of the cardiovascular safety strategy within AZ.   

Qualifications
Essential Requirements 
A degree in Biological Sciences/Bioengineering
Experience working within a laboratory environment
Technically minded with enthusiasm and aptitude for tackling unfamiliar aspects of cardiovascular safety science
Proficient with aseptic mammalian cell culture
Excellent interpersonal skills

 
Desirable Requirements 
Quantitative real-time PCR 
Fluorescent microscopy
Cellular transfections


About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 


At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.