Tissue Imaging Scientist - Imaging & AI at AstraZeneca

Do you have expertise in tissue imaging, and would like to be a part of an Imaging & AI team who has direct impact on drug development, playing a key role in bringing medicines to patients? Then come join us at AstraZeneca in Gothenburg Sweden, as our new Tissue Imaging Scientist.

As a Tissue Imaging Scientist you will play a pivotal role in delivering high quality imaging data, employing core histology and advanced molecular techniques, involving (multiplex) immunohistochemistry, immunofluorescence and in situ hybridisation method development as well as antibody characterisation to support projects. In this role you will be a part of our Imaging & AI team working within the Clinical Pharmacology and Safety Sciences (CPSS) organisation.

Clinical Pharmacology and Safety Sciences (CPSS) is changing the way imaging technologies are combined to offer unprecedented insight and impact. Our imaging hubs combine data from histology, digital pathology, multiplex assays, advanced molecular imaging techniques (including mass spectrometry imaging) and a full suite of in vivo imaging technologies.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you'll do:
As a Tissue Imaging Scientist you will be involved in the delivery of the histology component of early investigative in vivo safety studies, working with the local imaging hub lead, pathologists and study directors to deliver data to required quality standards and timelines. In addition, you will provide expert application of imaging technologies to advise on efficacy of new therapies.

You will also lead the design of tissue imaging endpoints, primarily with histological and molecular pathology-based techniques, and provide general and hypothesis-driven scientific advice on specific topics to the team. To do this, you need to have a strong understanding of the practices, principles and concepts associated with a variety of study types using both histological/molecular pathology techniques and other tissue imaging technologies within the group. Additional responsibilities:

* Help develop and apply advanced molecular techniques including multiplex immunohistochemistry/immunofluorescence and in situ hybridisation.
* Dynamically deliver standard safety histology endpoints, directly or through CRO outsourcing.
* Maintain knowledge internally and externally of new trends in tissue imaging technology, experimental techniques/equipment and introduce new methods and instrumentation as required and agreed with the Imaging & AI Leadership Team.
* Learn to perform basic image analysis using commercial software solutions.

Essential in the role:

* PhD or Graduate (mouse biology, molecular biology, biotechnology etc.) with strong experience in a relevant field.
* Expert knowledge in at least one of the following: immunohistochemistry, immunofluorescence, in situ hybridisation.
* Knowledge of histomorphology of mammalian tissue/s.
* Independent experimental design, critical data analysis (including statistics) and reporting.
* Comprehensive core knowledge of histology techniques.
* Problem-solving skills related to molecular pathology data analysis.

We also believe that the successful candidate enjoys collaborating, communicating and being a supportive colleague in our great team. This goes hand in hand with your problem-solving skills and strong delivery and goal focus. If you possesses leadership skills within small teams and on individual projects that's a plus to take on this role.

Desirable in the role:

* Experience in the pharmaceutical industry or hospital molecular pathology laboratory.
* Practical knowledge of multiplex immunohistochemistry/immunofluorescence methodology.
* Experience in image analysis using commercial software solutions.
* Understanding of other disciplines within pharmaceutical R&D.

Why AstraZeneca?
Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. Embrace an environment built on lifelong learning. Never complacent, we seek opportunities to expand our knowledge. The place to build a long-term meaningful career.

So, what's next? If this sounds like your next challenge - welcome to apply today!

We look forward to get to know you better, please submit your application no later than October 19th, 2021.

For more information about the position please contact Hiring Manager, Bjarki Johannesson at bjarki.johannesson@astrazeneca.com

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html