Transgenics Specialist - Senior Research Scientist

Are you a motivated cell and molecular biologist with experience and great knowledge in transgenic science? Do you want to apply this knowledge in a role that is connected to our wider mission to show what science can do? Then AstraZeneca has the position for you!

The Translational Models team at AstraZeneca in Gothenburg, Sweden are looking for a Senior Research Scientist/Associate Principal Scientist who has expertise in the area of precise genome editing and its application in both transgenic animal model generation and cellular engineering.

You will be part of the Translational Genomics group in the broader global Discovery Sciences function within Biopharmaceutical R&D. In the role you will devise, champion and develop scientific areas aligned with project needs and be a specialist in the area of molecular biology, in vivo science and precise genome editing - lead this from a lab-based perspective and to make significant contributions to the practical delivery of project goals.

What you will do:
In this position we rely you to design genome editing-based strategies and tools, required to generate in vivo and in vitro reagents to create disease models. To perform genetic screens in vitro and in vivo using genome editing tools and target validation studies in early projects. As well as perform complete confirmation assays of genetic manipulation and functional validation of engineered animals.

You will also mentor and support more junior scientists by advising and challenging them and providing expert advice to aid interpretation of complex data. You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals.

Essential requirements:
You should have a Ph.D. degree or corresponding experience in a relevant scientific field with experience in drug discovery or, alternatively, a first degree and proven experience in drug discovery.

The following skills are highly desirable:

* Molecular biology expertise and experience of working with mouse embryonic stem cells.
* Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
* Expertise in the generation and characterization of transgenic animal models.
* Generation and use of viral vectors (lentivirus, AAV, Adenovirus) for in vitro and in vivo genetic engineering.

The following skills would be an advantage:

* Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice.
* Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.

The successful candidate also possesses good social and communication skills, is collaborative and a standout colleague. You should also be able to work independently and have a positive, result oriented and problem-solving attitude. Excellent English is required, both spoken and written, and overall strong interpersonal skills are significant.

Does this sound like the next challenge for you? Apply today!

We look forward to your application no later than 24th January, 2021.

More information
For more information about the position please contact hiring manager John Wiseman at +46-(0)31-7065417 or john.w.wiseman@astrazeneca.com.

Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to develop a working environment that furthers collaboration, openness and innovation. Therefore, we have created space for meetings, and socializing, where spontaneous meetings can give birth to new innovations.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/

NOTE - Due to the holidays coming up, the screening process will take a bit longer than usual. Please bear with us and we will get back to you as soon as possible when we are back in January.