Transgenics Specialist - Senior Research/Principal Scientist

Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Researcher/Associate Principal Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, apply today!

We are looking for an expert in the area of precise genome editing and its application in both transgenic animal model generation and cellular engineering. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of in vivo science and precise genome editing - to lead this from a lab-based perspective and to make significant contributions to the practical delivery of project goals.

In this role, you will also coach and support more junior scientists by advising and challenging them and providing expert advice to aid interpretation of complex data. You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. Along with this, you will propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

We see that you have good social and communication skills, is collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organisational skills are of use.

The following skills are highly desirable:

* Molecular biology expertise and experience of working with mouse embryonic stem cells.
* Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
* Expertise in the generation and characterization of transgenic animal models
* Generation and use of viral vectors (lentivirus, AAV, Adenovirus) for in vitro and in vivo genetic engineering

The following skills would be an advantage:

* Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice.
* Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.

Minimum experience:

* You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

Generic component of SRS role descriptor

Accountabilities

* To design genome editing-based strategies and tools required to generate in vivo and in vitro reagents to create disease models
* To perform genetic screens in vitro and in vivo using genome editing tools
* To perform confirmation assays of genetic manipulation and functional validation of engineered animals
* To perform target validation studies in early projects

We look forward to your application no later than 22nd March, 2020.

More information
For more information about the position please contact hiring manager John Wiseman at +46-(0)31-7065417 or john.w.wiseman@astrazeneca.com.